Clean-in-place (CIP) is a method of cleaning the interior surfaces of vessels, pipes, process equipment, and associated fittings, without major disassembly. They are normally skid mounted stationary or portable systems, integrating one or more tanks and centrifugal pumps for water, detergents or chemicals and semi to fully automatic controls. A typical system would incorporate a wetting/rinse phase, an additional detergent/wash phase, and final flush/rinse phase. Sanitary process industries that rely heavily on CIP are those that require high levels of hygiene such as: dairy, beverages, processed food, cosmetics, pharmaceuticals, and brewing. System sizes and GPM requirements vary depending on the size and number of units needed to be cleaned. CIP is commonly used for cleaning bioreactors, fermenters, mix vessels, and other equipment used in biotech manufacturing, pharmaceutical manufacturing and food and beverage manufacturing. CIP is performed to remove or obliterate previous Cell Culture batch components. It is used to remove in-process residues, control bioburden, and reduce endotoxin levels within processing equipment and systems. Residue removal is accomplished during CIP with a combination of heat, chemical action, and turbulent flow. Major manufacturers are: Processtec and Sani-Matic, Hartel, Entegis, Santasalo, Martin Peterson, Dober Group, G&H Products, Electrol Specialties, Custom Steel Fabricating, Strahman, Thomas Engineering.
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